Footnotes

• Contributors NSMP contributed the collection of images with OCT, the project plan, data analysis and manuscript writing. ATD contributed to the clinical appointments, project plan, statistical analysis and manuscript writing. ALBPD contributed with the project plan and manuscript writing. MMA contributed with the all computational analysis using Matlab. LOF contributed with the project plan and data analysis. TJCD and LSAM contributed to the collection of OCT images. ASLG coordinated the study, as well as reviewed the data and the manuscript writing.

• Competing interests None declared.

• Ethics approval CEP-CCS-UFPE.

• Provenance and peer review Not commissioned; externally peer reviewed.