Footnotes

• Contributors OL, the corresponding author, states that all the authors listed have contributed to the work.

• Funding LA: research funding: Novartis, Pfizer.

• Competing interests Honoraria: SC for Bristol-Myers Squibb, Janssen, Merck Sharp & Dohme and Roche. LA for Novartis, Pfizer, BMS, Sanofi and Ipsen. OL for Merck Sharp Dohme and Genzyme.

• Ethics approval Gustave Roussy ethical committee.

• Provenance and peer review Not commissioned; externally peer reviewed.

• ↵i Registre des Effets Indésirables Sévères des Anticorps Monoclonaux Immunomodulateurs en Cancérologie.