Footnotes

• Contributors Conceptualisation: CID, JM, PF, JB, BC. Methodology: CID, PF, FR, TM. Software: TM, CID, PF. Formal analysis: CID, AT, TM. Investigation: CID, AT, GdC, JM, BC, PF, FR. Resources: CID, JM, PF, JB, BC. Writing (original draft preparation): CID, AT. Writing (review and editing): JB, FR, GdC, JM, BC, TM, PF. Supervision: CID, BC, PF, JB. Project administration: CID, BC, PF, JB.

• Funding MACVIA-LR.

• Competing interests CID has received honoraria from BMS, MSD, Pfizer, Roche-Chugai, and UCB, and research grants from MSD, Pfizer, Roche-Chugai and UCB. PLEASE REPORT SIMILAR COMPETING INTEREST AT THE END OF THE MANUSCRIPT

• Provenance and peer review Not commissioned; externally peer reviewed.