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  • Response to: ‘Correspondence on ‘Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study’ by Lee

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Correspondence response
Response to: ‘Correspondence on ‘Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study’ by Lee
  1. Jiangwei Xia1,2,
  2. Lin Xu3,
  3. Ke-Qi Liu4,
  4. Zhi-Min Ying5,
  5. Shu-Yang Xie3,
  6. Hou-Feng Zheng1,2
  1. 1 Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China
  2. 2 Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, Zhejiang, China
  3. 3 Binzhou Medical University, Yantai, Shandong, China
  4. 4 Jiangxi Medical College, Shangrao, Jiangxi, China
  5. 5 Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
  1. Correspondence to Dr Hou-Feng Zheng, Diseases & Population Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; zhenghoufeng{at}westlake.edu.cn

https://doi.org/10.1136/annrheumdis-2020-218906

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    We appreciate Dr Young Ho Lee’s interest in our study on the relationship between psoriatic arthritis (PsA) and osteoporosis,1 and thank him for the comments brought in his letter.2

    Over the past few years, several methods were developed to deal with the pleiotropic effect of instrumental single-nucleotide polymorphisms (SNPs) in Mendelian randomisation (MR) analysis, such as inverse variance-weighted (IVW), MR Egger, the weighted median,3 weighted (simple) mode-based4 and Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO).5 However, the limitation of each method should be acknowledged.6 The weighted median method estimated some SNPs as invalid instruments, …

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    Footnotes

    • Handling editor Josef S Smolen

    • Contributors All authors contributed to the conception and drafting of the manuscript. All authors provided critical revision and final approval.

    • Funding This work was supported by the National Natural Science Foundation of China (81871831) and by the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China (LR17H070001).

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Commissioned; internally peer reviewed.

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