Footnotes

• Handling editor Josef S Smolen

• Twitter @stezhao, @dpsg108

• Contributors All authors contributed to writing and interpretation and approved of the final draft for submission.

• Funding SSZ is supported by a National Institute for Health Research Clinical Lectureship. VK is supported by the Academy of Finland Project 312123, and European Union’s Horizon 2020 research and innovation programme under Grant Agreement No 848158. APM is supported by Versus Arthritis (grant reference 21754). DG is supported by the British Heart Foundation Research Centre of Excellence (RE/18/4/34215) at Imperial College London and by a National Institute for Health Research Clinical Lectureship (CL-2020-16-001) at St. George’s, University of London.

• Competing interests None declared.

• Provenance and peer review Not commissioned; externally peer reviewed.

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