PT  - JOURNAL ARTICLE
AU  - Hakala, M
AU  - Aho, K
AU  - Åman, S
AU  - Luukkainen, R
AU  - Kauppi, M
AU  - Risteli, J
TI  - Type I collagen degradation does not diminish with RA disease duration
AID  - 10.1136/ard.60.4.420
DP  - 2001 Apr 01
TA  - Annals of the Rheumatic Diseases
PG  - 420--422
VI  - 60
IP  - 4
4099  - http://ard.bmj.com/content/60/4/420.short
4100  - http://ard.bmj.com/content/60/4/420.full
SO  - Ann Rheum Dis2001 Apr 01; 60
AB  - OBJECTIVE To assess the relation between type I collagen degradation and the duration of rheumatoid arthritis (RA).METHODS The serum concentrations of cross linked carboxyterminal telopeptide of type I collagen (ICTP) measured earlier in a community based series (90 patients) and a hospital based series (59 patients) were re-evaluated with reference to the duration of RA.RESULTS The serum ICTP showed a positive correlation with the duration of the disease in the hospital based series (r s=0.40, p<0.01) but not in the community based one (r s=0.18, p=0.10).CONCLUSIONS Type I collagen degradation predominantly reflecting pathological bone destruction does not seem to diminish in longlasting RA.