RT Journal Article
SR Electronic
T1 Type I collagen degradation does not diminish with RA disease duration
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 420
OP 422
DO 10.1136/ard.60.4.420
VO 60
IS 4
A1 Hakala, M
A1 Aho, K
A1 Åman, S
A1 Luukkainen, R
A1 Kauppi, M
A1 Risteli, J
YR 2001
UL http://ard.bmj.com/content/60/4/420.abstract
AB OBJECTIVE To assess the relation between type I collagen degradation and the duration of rheumatoid arthritis (RA).METHODS The serum concentrations of cross linked carboxyterminal telopeptide of type I collagen (ICTP) measured earlier in a community based series (90 patients) and a hospital based series (59 patients) were re-evaluated with reference to the duration of RA.RESULTS The serum ICTP showed a positive correlation with the duration of the disease in the hospital based series (r s=0.40, p<0.01) but not in the community based one (r s=0.18, p=0.10).CONCLUSIONS Type I collagen degradation predominantly reflecting pathological bone destruction does not seem to diminish in longlasting RA.