PT  - JOURNAL ARTICLE
AU  - Scherer, Hans Ulrich
AU  - van der Linden, Michael P M
AU  - Kurreeman, Fina A S
AU  - Stoeken-Rijsbergen, Gerrie
AU  - Cessie, Saskia le
AU  - Huizinga, Tom W J
AU  - van der Helm-van Mil, Annette H
AU  - Toes, René E M
TI  - Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis
AID  - 10.1136/ard.2008.106161
DP  - 2010 Mar 01
TA  - Annals of the Rheumatic Diseases
PG  - 567--570
VI  - 69
IP  - 3
4099  - http://ard.bmj.com/content/69/3/567.short
4100  - http://ard.bmj.com/content/69/3/567.full
SO  - Ann Rheum Dis2010 Mar 01; 69
AB  - Background Two novel genetic polymorphisms on chromosome 6q23 are associated with susceptibility to rheumatoid arthritis (RA). Both polymorphisms (rs6920220 and rs10499194) reside in a region close to the gene encoding tumour necrosis factor α-induced protein 3 (TNFAIP3). TNFAIP3 is a negative regulator of NF-κB and is involved in inhibiting TNF-receptor-mediated signalling effects. Interestingly, the initial associations were detected in patients with longstanding RA. However, no association was found for rs10499194 in a Swedish cohort with early arthritis. This might be caused by over-representation of patients with severe disease in cohorts with longstanding RA. Objective To analyse the effect of the 6q23 region on the rate of joint destruction. Methods Five single nucleotide polymorphisms in 6q23 were genotyped in 324 Dutch patients with early RA. Genotypes were correlated with progression of radiographic joint damage for a follow-up time of 5 years. Results Two polymorphisms (rs675520 and rs9376293) were associated with severity of radiographic joint damage in patients positive for anti-citrullinated protein/peptide antibodies (ACPA). Importantly, the effects were present after correction for confounding factors such as secular trends in treatment. Conclusions These data associate the 6q23 region with the rate of joint destruction in ACPA+ RA.