PT  - JOURNAL ARTICLE
AU  - Xu, HanLin
AU  - Qin, Hengwei
AU  - Hua, YingHui
AU  - Dalbeth, Nicola
TI  - Contributions of joint damage-related events to gout pathogenesis: new insights from laboratory research
AID  - 10.1136/ard-2023-224679
DP  - 2023 Dec 01
TA  - Annals of the Rheumatic Diseases
PG  - 1511--1515
VI  - 82
IP  - 12
4099  - http://ard.bmj.com/content/82/12/1511.short
4100  - http://ard.bmj.com/content/82/12/1511.full
SO  - Ann Rheum Dis2023 Dec 01; 82
AB  - Epidemiological and imaging findings indicate that gout frequently affects damaged joints. Recent studies suggest that the relationship between gout and joint damage may be more complex than a simple unidirectional link and that joint damage may promote the development of gout at affected sites. In this article, we review the clinical associations and recent laboratory research identifying events in the setting of osteoarthritis or joint injury that can alter the intraarticular microenvironment and locally regulate monosodium urate crystallisation and deposition or amplify the inflammatory response to deposited crystals. This includes cartilage matrix proteins or fibres released into the articular space that accelerates the crystallisation process, as well as the lack of lubricin and fibroblast priming that enhances the immune response towards the deposited crystals. These findings provide new insights into gout pathogenesis and offer a possible explanation for the site preference of gout in the damaged joint.