Genetic association of Hsp70 haplotypes with SLE in the Erlangen cohort
| Frequency of major allele (%) | Single marker association | ||||
|---|---|---|---|---|---|
| SNP No | rs No | Major/minor allele | SLE (n=212) | Controls (n=223) | (p value) |
| Hsp70-1 | rs2075800 | C/T | 68.0 | 65.7 | 0.4792 |
| Hsp70-2 | rs2227956 | A/G | 81.4 | 83.0 | 0.5483 |
| Hsp70-3 | rs1043618 | G/C | 60.2 | 65.3 | 0.1306 |
| Hsp70-4 | rs2763979 | C/T | 61.0 | 68.8 | 0.0160 |
| Hsp70-5 | rs3115673 | G/T | 88.3 | 87.4 | 0.6902 |
| Frequency of haplotype (%) | Haplotype association | |||
|---|---|---|---|---|
| Haplotype | Overall frequency | SLE (n=212) | Controls (n=223) | (p value) |
| T–A–G–C–G | 32.7 | 32.1 | 33.3 | 0.7034 |
| C–A–C–T–G | 21.4 | 25.8 | 17.2 | 0.0022 |
| C–G–G–C–G | 16.5 | 16.2 | 16.8 | 0.7999 |
| C–A–C–T–T | 9.2 | 9.0 | 9.5 | 0.8023 |
| C–A–G–C–G | 8.3 | 6.9 | 9.7 | 0.1455 |
| C–A–C–C–G | 6.4 | 4.7 | 8.1 | 0.0444 |
| C–A–G–T–T | 2.9 | 2.6 | 3.1 | 0.6311 |
SLE, systemic lupus erythematosus; SNP, single-nucleotide polymorphism.