Increase in dose or dosing frequency by age-group and phenotype
| Adjustments | Total n=166 | Adult n=119 | Paediatric n=47 | FCAS n=30 | MWS n=103 | NOMID/CINCA n=32 |
|---|---|---|---|---|---|---|
| Dose or frequency adjustments | 40 (24.1) | 23 (19.3) | 17 (36.2) | 5 (16.6) | 20 (19.4) | 15 (46.9) |
| Dose adjustments | 36 (21.7) | 20 (16.8) | 16 (34.0) | 5 (16.6) | 17 (16.5) | 14 (43.8) |
| Frequency adjustments | 19† (11.4) | 8 (6.7) | 11 (23.4) | 0 | 11 (10.7) | 8 (25.0) |
↵† Reduced in 17, increased in two patients on at least one instance.
CINCA, chronic infantile neurological cutaneous and articular syndrome; FCAS, familial cold autoinflammatory syndrome; MWS, Muckle–Wells syndrome; NOMID, neonatal-onset multisystem inflammatory disease.