Table 4

Conventional Cox-proportional hazard regression analysis with time to first CVD event as the primary outcome and time-averaged DAS28 as the primary independent variable, before (panel A) and after (panel B) correction for confounders

	Beta	p Value	HR	95% CI for Exp (B)
	Beta	p Value	HR	Lower	Upper
Panel A: Crude model
Time-averaged DAS28	0.383	<0.001	1.466	1.204	1.786
Age	0.060	<0.001	1.062	1.043	1.082
Gender	0.848	<0.001	2.336	1.549	3.521
Panel B: Full model
Time-averaged DAS28	0.468	<0.000	1.597	1.279	1.994
Age	0.056	<0.001	1.057	1.037	1.077
Gender	0.954	<0.001	2.595	1.712	3.933
Hypertension baseline	0.920	<0.001	2.508	1.566	4.018
DAS28 baseline	−0.048	0.587	0.953	0.802	1.133
Panel D: Full model
Time-averaged DAS28 binary; (≤3.2)	−0.630	0.007	0.533	0.337	0.843
Age	0.058	<0.001	1.060	1.040	1.080
Gender	0.803	<0.001	2.231	1.491	3.339
Hypertension baseline	0.882	<0.001	2.417	1.506	3.879
DAS28 baseline	0.042	0.614	1.043	0.886	1.228

DAS28, 28-joint disease activity score.