Association of baseline SUA level and incident dementia: sensitivity analyses using the usual hyperuricemia threshold or an alternate date of disease
Hyperuricemia* | Model 1† | Model 2‡ | Model 3§ | Model 4¶ | ||||||
Hyperuricemia | % (N) | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
All-cause dementia (n=110) | ||||||||||
No | 6.2 (78) | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | |||||
Yes | 9.6 (32) | 1.36 (0.90; 2.07) | 0.15 | 1.47 (0.93; 2.31) | 0.10 | 1.45 (0.92; 2.29) | 0.11 | 1.51 (0.95; 2.39) | 0.08 | |
Alzheimer’s disease (n=76) | ||||||||||
No | 4.4 (55) | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | |||||
Yes | 6.5 (21) | 1.25 (0.75; 2.09) | 0.39 | 1.35 (0.78; 2.36) | 0.29 | 1.35 (0.77; 2.36) | 0.29 | 1.38 (0.79; 2.43) | 0.26 | |
Vascular or mixed dementia (n=20) | ||||||||||
No | 1 (12) | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | |||||
Yes | 2.6 (8) | 2.07 (0.84; 5.07) | 0.11 | 2.02 (0.71; 5.77) | 0.19 | 1.9 (0.65; 5.56) | 0.24 | 1.88 (0.64; 5.49) | 0.25 |