Baseline characteristics of the study sample and association with baseline SUA level
| Total sample, | Baseline high SUA level* | |||
| n=1598 | No (n=1192) | Yes (n=406) | p† | |
| Age, years, mean (SD) | 72.4 (4.1) | 72.2 (4.1) | 72.9 (4.1) | 0.002 |
| Male | 612 (38.3) | 455 (38.2) | 157 (38.7) | 0.86 |
| High education level‡ | 654 (40.9) | 501 (42.0) | 153 (37.7) | 0.12 |
| Current drinker (>2 drinks/week) | 332 (22.6) | 231 (21.1) | 101 (27.2) | 0.07 |
| Current smoking | 92 (5.8) | 67 (5.6) | 25 (6.2) | 0.008 |
| BMI, kg/m2, mean (SD) | 25.4 (3.8) | 24.8 (3.7) | 27.1 (3.7) | <0.0001 |
| Glomerular filtration rate, mL/min/1.73m2, mean (SD) | 75.1 (13.7) | 76.8 (13.3) | 70.2 (13.7) | <0.0001 |
| Hypertension | 1209 (75.7) | 861 (72.2) | 348 (85.7) | <0.0001 |
| Diabetes mellitus | 121 (7.6) | 87 (7.3) | 34 (8.4) | 0.47 |
| History of cardiovascular disease | 91 (5.7) | 57 (4.8) | 34 (8.4) | 0.007 |
| NSAIDs use | 239 (15.1) | 178 (15.1) | 61 (15.1) | 0.99 |
| Concomitant use of aspirin or diuretics | 424 (26.6) | 270 (22.7) | 154 (38.0) | <0.0001 |
| APOE ε4 carrier | 347 (21.7) | 269 (22.6) | 78 (19.2) | 0.16 |
| LDL-c level, mmol/L, mean (SD) | 3.58 (0.81) | 3.59 (0.81) | 3.55 (0.83) | 0.38 |
| HDL-c level, mmol/L, mean (SD) | 1.65 (0.40) | 1.68 (0.40) | 1.55 (0.40) | <0.0001 |
| Triglycerides level, mmol/L, mean (SD) | 1.20 (0.56) | 1.13 (0.51) | 1.40 (0.62) | <0.0001 |
| High CRP level§ | 537 (33.6) | 375 (31.5) | 162 (39.9) | 0.005 |
| High IL-6 level¶ | 411 (25.7) | 278 (23.3) | 133 (32.8) | <0.0001 |
| SUA level, μmol/L, mean (SD) | 273.7 (70.4) | 244.2 (48.3) | 360.3 (51.1) | <0.0001 |
*SUA level ≥ 75th percentile of distribution, gender dependent (345 μmol/L for men; 292 μmol/L for women).
†Analysis of covariance for continuous variables; χ2 test for categorical variables.
‡High school or university diploma.
§CRP level ≥ 66th percentile of distribution (≥2.49 mg/L).
¶IL-6 level ≥ median of distribution (≥4.0 pg/mL).
APOE, apolipoprotein E; BMI, body mass index; CRP, C reactive protein; HDL-c, high-density lipoprotein cholesterol; IL, interleukin; LCL-c, low-density lipoprotein cholesterol; NSAIDs, non-steroidal anti-inflammatory drugs; SUA, serum uric acid.
Values are number (percentage) unless stated otherwise.