Increasing VCA IgG and EA IgG levels are associated with transitioning to SLE*
| Serological measures | Transitioned (n=56) versus non-transitioned (n=380) relatives OR (95% CI), p value | Transitioned relatives (n=56) versus unrelated unaffected controls (n=122) OR (95% CI), p value |
| VCA IgG (OD ratio) | 1.28 (1.07 to 1.53), 0.007 | 1.30 (1.02 to 1.65), 0.03 |
| VCA IgA (OD ratio) | 0.99 (0.78 to 1.27), 0.94 | 1.01 (0.73 to 1.42), 0.91 |
| EA IgG (OD ratio) | 1.43 (1.06 to 1.93), 0.02 | 2.11 (1.38 to 3.23), 0.0005 |
| CMV IgG (OD ratio) | 1.03 (0.87 to 1.22), 0.72 | 0.89 (0.73 to 1.07), 0.21 |
| HSV-1 IgG (OD ratio) | 1.06 (0.92 to 1.22), 0.44 | 0.94 (0.82 to 1.09), 0.43 |
Statistically significant values (p<0.05) are in bold
*OR presented for one unit increase in OD ratio.
CMV, cytomegalovirus; EA, early antigen; HSV, herpes simplex virus; OD, optical density; SLE, systemic lupus erythematosus; VCA, viral capsid antigen.