CpGs that were differentially methylated in the same direction in both blood and in buccal epithelial cells
| CpG | Beta* | SE | P value | Nearest gene (±bp) | Chr | bp | Location† |
| cg22998206 | 0.1029 | 0.022 | 4.40×10−06 | – | 12 | 49 239 429 | – |
| cg03654106 | 0.0727 | 0.016 | 9.50×10−06 | – | 19 | 49 539 527 | – |
| cg02613964 | −0.058 | 0.014 | 7.57×10−05 | – | 3 | 44 690 321 | – |
| cg11336323 | −0.092 | 0.024 | 1.63×10−04 | – | 19 | 41 946 040 | Promoter |
*Beta represents the difference in DNA methylation at the given CpG site in buccal epithelial cells from children born to mothers with RA (FEPRA study) as compared with blood samples from children born to mothers from the general population (Generation R Study).
†Location in promoter, gene, enhancer or unknown (–).
bp, base pair; Chr, chromosome; CpG, cytosine-phosphate-guanine; FEPRA, FEtal Programming in Rheumatoid Arthritis; RA, rheumatoid arthritis.