Predictors at start of follow-up of mortality among PsA cases and comparator-subjects
| Proportion at start of follow-up, PsA cases/comparator-subjects | PsA cases HR (95% CI)* | Population comparator-subjects HR (95% CI)* | |
| Higher education (>12 y vs ≤12 y) | 28/32% | 0.66 (0.60 to 0.73) | 0.65 (0.62 to 0.68) |
| General comorbidities | |||
| Cardiovascular disease† | 41/31% | 1.79 (1.64 to 1.95) | 1.67 (1.61 to 1.74) |
| Diabetes mellitus† | 8.6/5.9% | 1.82 (1.66 to 1.98) | 1.91 (1.82 to 2.00) |
| Infection‡ | 48/34% | 1.60 (1.49 to 1.71) | 1.65 (1.59 to 1.71) |
| Chronic pulmonary disease‡ | 6.8/4.0% | 2.03 (1.84 to 2.24) | 2.21 (2.08 to 2.34) |
| Chronic kidney disease‡ | 0.8/0.4% | 4.61 (3.85 to 5.51) | 3.90 (3.48 to 4.38) |
| Malignancy‡ | 7.3/6.6% | 1.63 (1.49 to 1.78)§ | 1.76 (1.69 to 1.84) |
| Anxiety/depression† | 29/22% | 1.58 (1.47 to 1.71)§ | 1.89 (1.82 to 1.96) |
| Joint surgery | |||
| Hip and/or knee replacement surgery‡ | 4.7/2.4% | 1.37 (1.24 to 1.52)§ | 1.15 (1.07 to 1.23) |
| Other joint surgery (small or large joints)‡ | 6.3/2.0% | 1.27 (1.13 to 1.42) | 1.15 (1.04 to 1.28) |
*Separate sex-/age-adjusted models.
†≥1 relevant ICD-code in the NPR and/or ≥1 relevant drug dispensation in the PDR prior to start of follow-up.
‡≥1 relevant ICD/procedure-code in NPR prior to start of follow-up.
§In the entire material, the interaction terms between the PsA case/comparator-subject status and these predictors were significant (malignancy p=0.014; anxiety/depression p<0.001; hip/knee replacement surgery p=0.024), indicating a difference of the predictive ability in the two groups.
ICD, International Classification of Diseases; NPR, National Patient Register; PDR, Prescribed Drugs Register; PsA, psoriatic arthritis; y, years.