During the past 12 years both clinicians and researchers involved in rheumatology, haematology, clinical immunology, and gynaecology have been inundated with hundreds of manuscripts regarding the so called antiphospholipid syndrome (APS).

As a result of the spread of information about the pathogenesis and clinical aspect of antiphospholipid antibodies (APA) in humans, ‘non-professional APA readers’ have been often puzzled by APA characterisation, criteria for APS definition, reliability of assays for APA detection, and APS management.

None the less, thanks to the growing number of clinical findings concerning APS, it has became apparent …