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Type I collagen degradation does not diminish with RA disease duration
  1. M Hakalaa,
  2. K Ahoc,
  3. S Åmana,
  4. R Luukkainend,
  5. M Kauppia,e,
  6. J Ristelib
  1. aDivision of Rheumatology, Department of Internal Medicine, University of Oulu, Oulu, Finland, bDepartment of Clinical Chemistry, University of Oulu, cNational Public Health Institute, Helsinki, Finland, dDepartment of Rheumatology, Satalinna Hospital, Harjavalta, Finland, eRheumatism Foundation Hospital, Heinola, Finland
  1. Dr M Hakala, Department of Internal Medicine, University of Oulu, FIN-90220 Oulu, Finlandmarkku.hakala{at}oulu.fi

Abstract

OBJECTIVE To assess the relation between type I collagen degradation and the duration of rheumatoid arthritis (RA).

METHODS The serum concentrations of cross linked carboxyterminal telopeptide of type I collagen (ICTP) measured earlier in a community based series (90 patients) and a hospital based series (59 patients) were re-evaluated with reference to the duration of RA.

RESULTS The serum ICTP showed a positive correlation with the duration of the disease in the hospital based series (r s=0.40, p<0.01) but not in the community based one (r s=0.18, p=0.10).

CONCLUSIONS Type I collagen degradation predominantly reflecting pathological bone destruction does not seem to diminish in longlasting RA.

  • ICTP
  • radiography
  • joint destruction
  • rheumatoid arthritis

https://doi.org/10.1136/ard.60.4.420

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