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Letter
Cogan's syndrome with antineutrophil cytoplasmic autoantibody
  1. M Ikeda1,
  2. H Okazaki2,
  3. S Minota2
  1. 1Health Science Centre, Utsunomiya University, Tochigi, Japan
  2. 2Division of Rheumatology and Clinical Immunology, Jichi Medical School, Tochigi, Japan
  1. Correspondence to:
    Dr M Ikeda, Health Science Centre, Utsunomiya University, Utsunomiya City, Tochigi 321–8505, Japan;
    ikedam{at}cc.utsunomiya-u.ac.jp

https://doi.org/10.1136/ard.61.8.761

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    Cogan's syndrome is a rare disease characterised by non-syphilitic interstitial keratitis with vestibuloauditory dysfunction, including loss of hearing, tinnitus, and vertigo.1 We report here a case of Cogan's syndrome positive for antineutrophil cytoplasmic antibody (ANCA). This case is interesting in consideration of the pathogenesis of this syndrome.

    CASE REPORT

    In May 1999 a 61 year old man was admitted to our hospital with fever and myalgia localised to the lower part of both legs. He had a history of lung tuberculosis at 22 years old, chronic sinusitis at 30, and bilateral otitis media at 53. On admission, laboratory tests showed a white blood cell count of 11.2×109/l and a CRP level of 63 mg/l. Serum levels of creatine kinase, alanine aminotransferase, and aspartate aminotransferase, and a urinary examination were normal. A serological test was positive for perinuclear ANCA (pANCA) and myeloperoxidase ANCA (MPO-ANCA; 105 EU/ml (normal <10 EU/ml)), but negative …

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