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  • Serum levels of monocyte chemotactic protein-3/CCL7 are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis

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Serum levels of monocyte chemotactic protein-3/CCL7 are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis
  1. K Yanaba1,
  2. K Komura1,
  3. M Kodera1,
  4. T Matsushita1,
  5. M Hasegawa1,
  6. K Takehara1,
  7. S Sato2
  1. 1Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
  2. 2Department of Dermatology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
  1. Correspondence to:
    Dr S Sato
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Science, 1–7–1 Sakamoto, Nagasaki, 852–8501, Japan; s-sato{at}net.nagasaki-u.ac.jp

Abstract

Objective: To determine serum levels of monocyte chemotactic protein-3 (MCP-3) and its clinical associations in patients with systemic sclerosis (SSc).

Methods: Serum MCP-3 levels from 69 patients with SSc were examined by ELISA.

Results: Serum MCP-3 levels were raised in patients with SSc (n = 69) compared with healthy controls (n = 28). Patients with diffuse cutaneous SSc (n = 36) had higher levels of serum MCP-3 than those with limited cutaneous SSc (n = 33). Patients with raised MCP-3 levels had pulmonary fibrosis and decreased vital capacity (VC) more often than those with normal MCP-3 levels. MCP-3 levels correlated positively with the extent of skin fibrosis, and inversely with %VC and carbon monoxide transfer factor (Tlco) in patients with SSc.

Conclusion: MCP-3 levels were increased in patients with SSc, and correlated with the extent of skin sclerosis and the severity of pulmonary fibrosis. These results suggest that MCP-3 may have a role in the development of fibrosis in SSc.

  • Abs, antibodies
  • dSSc, diffuse cutaneous SSc
  • ELISA, enzyme linked immunosorbent assay
  • lSSc, limited cutaneous SSc
  • MCP, monocyte chemotactic protein
  • PF, pulmonary fibrosis
  • SSc, systemic sclerosis
  • Tlco, carbon monoxide transfer factor
  • VC, vital capacity
  • systemic sclerosis
  • MCP-3
  • pulmonary fibrosis
  • skin sclerosis

https://doi.org/10.1136/ard.2005.040782

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