Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

Christian Beyer; Jingang Huang; Jürgen Beer; Yun Zhang; Katrin Palumbo-Zerr; Pawel Zerr; Alfiya Distler; Clara Dees; Christiane Maier; Louis Munoz; Gerhard Krönke; Stefan Uderhardt; Oliver Distler; Simon Jones; Stefan Rose-John; Tamas Oravecz; Georg Schett; Jörg HW Distler

doi:10.1136/annrheumdis-2013-204401

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Basic and translational research

Extended report

Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

Authors

Christian Beyer Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Jingang Huang Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Jürgen Beer Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Yun Zhang Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Katrin Palumbo-Zerr Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Pawel Zerr Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Alfiya Distler Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Clara Dees Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Christiane Maier Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Louis Munoz Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Gerhard Krönke Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Stefan Uderhardt Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Oliver Distler Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland PubMed articles Google scholar articles
Simon Jones Cardiff Institute of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, UK PubMed articles Google scholar articles
Stefan Rose-John Institute of Biochemistry, Christian-Albrechts-University Kiel, Kiel, Germany PubMed articles Google scholar articles
Tamas Oravecz Lexicon Pharmaceuticals Inc., The Woodlands, Texas, USA PubMed articles Google scholar articles
Georg Schett Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Jörg HW Distler Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles

Correspondence to Dr Jörg Distler, Department of Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Ulmenweg 18, Erlangen D-91054, Germany; Joerg.distler{at}uk-erlangen.de

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Citation

Beyer C, Huang J, Beer J, et al

Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

Annals of the Rheumatic Diseases 2015;74:1317-1324.

Publication history

Received August 6, 2013
Revised January 31, 2014
Accepted February 16, 2014
First published March 11, 2014.

Online issue publication

October 31, 2019

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

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