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  • JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment

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Basic and translational research
Extended report
JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment

Authors

  • Yun Zhang Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Ruifang Liang Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Chih-Wei Chen Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Tatjana Mallano Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Clara Dees Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Alfiya Distler Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Adam Reich Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland PubMed articlesGoogle scholar articles
  • Christina Bergmann Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Andreas Ramming Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Kolja Gelse Department of Trauma Surgery, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany PubMed articlesGoogle scholar articles
  • Dirk Mielenz Division of Molecular Immunology, Nikolaus Fiebiger Center, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany PubMed articlesGoogle scholar articles
  • Oliver Distler Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland PubMed articlesGoogle scholar articles
  • Georg Schett Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Jörg H W Distler Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Jörg H W Distler, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, D-91054 Erlangen, Germany; joerg.distler{at}uk-erlangen.de
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Citation

Zhang Y, Liang R, Chen C, et al
JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment
Annals of the Rheumatic Diseases 2017;76:1467-1475.

Publication history

  • Received December 2, 2016
  • Revised February 28, 2017
  • Accepted April 9, 2017
  • First published May 6, 2017.
Online issue publication 
October 31, 2019

Copyright information

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.