Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients

Akiyoshi Nakayama; Masahiro Nakatochi; Yusuke Kawamura; Ken Yamamoto; Hirofumi Nakaoka; Seiko Shimizu; Toshihide Higashino; Teruhide Koyama; Asahi Hishida; Kiyonori Kuriki; Miki Watanabe; Toru Shimizu; Keiko Ooyama; Hiroshi Ooyama; Mitsuo Nagase; Yuji Hidaka; Daisuke Matsui; Takashi Tamura; Takeshi Nishiyama; Chisato Shimanoe; Sakurako Katsuura-Kamano; Naoyuki Takashima; Yuya Shirai; Makoto Kawaguchi; Mikiya Takao; Ryo Sugiyama; Yuzo Takada; Takahiro Nakamura; Hiroshi Nakashima; Masashi Tsunoda; Inaho Danjoh; Atsushi Hozawa; Kazuyoshi Hosomichi; Yu Toyoda; Yu Kubota; Tappei Takada; Hiroshi Suzuki; Blanka Stiburkova; Tanya J. Major; Tony R. Merriman; Nagato Kuriyama; Haruo Mikami; Toshiro Takezaki; Keitaro Matsuo; Sadao Suzuki; Tatsuo Hosoya; Yoichiro Kamatani; Michiaki Kubo; Kimiyoshi Ichida; Kenji Wakai; Ituro Inoue; Yukinori Okada; Nariyoshi Shinomiya; Hirotaka Matsuo

doi:10.1136/annrheumdis-2019-216644

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Crystal arthropathies

Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients

Authors

Akiyoshi Nakayama Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan Medical Squadron, Air Base Group, Western Aircraft Control and Warning Wing, Japan Air Self-Defense Force, Kasuga, Japan PubMed articles Google scholar articles
Masahiro Nakatochi Division of Department of Nursing, Nagoya University Graduate School of Medicine, Nagoya, Japan PubMed articles Google scholar articles
Yusuke Kawamura Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan Department of General Medicine, National Defense Medical College, Tokorozawa, Japan PubMed articles Google scholar articles
Ken Yamamoto Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan PubMed articles Google scholar articles
Hirofumi Nakaoka Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Japan PubMed articles Google scholar articles
Seiko Shimizu Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan PubMed articles Google scholar articles
Toshihide Higashino Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan PubMed articles Google scholar articles
Teruhide Koyama Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan PubMed articles Google scholar articles
Asahi Hishida Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan PubMed articles Google scholar articles
Kiyonori Kuriki Laboratory of Public Health, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan PubMed articles Google scholar articles
Miki Watanabe Department of Public Health, Nagoya City University Graduate School Medical Science, Nagoya, Japan PubMed articles Google scholar articles
Toru Shimizu Midorigaoka Hospital, Takatsuki, Japan Kyoto Industrial Health Association, Kyoto, Japan PubMed articles Google scholar articles
Keiko Ooyama Ryougoku East Gate Clinic, Tokyo, Japan PubMed articles Google scholar articles
Hiroshi Ooyama Ryougoku East Gate Clinic, Tokyo, Japan PubMed articles Google scholar articles
Mitsuo Nagase Nagase Clinic, Tokyo, Japan PubMed articles Google scholar articles
Yuji Hidaka Akasaka Central Clinic, Tokyo, Japan PubMed articles Google scholar articles
Daisuke Matsui Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan PubMed articles Google scholar articles
Takashi Tamura Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan PubMed articles Google scholar articles
Takeshi Nishiyama Department of Public Health, Nagoya City University Graduate School Medical Science, Nagoya, Japan PubMed articles Google scholar articles
Chisato Shimanoe Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan Clinical Research Center, Saga University Hospital, Saga, Japan PubMed articles Google scholar articles
Sakurako Katsuura-Kamano Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan PubMed articles Google scholar articles
Naoyuki Takashima Department of Health Science, Shiga University of Medical Science, Otsu, Japan Department of Public Health, Faculty of Medicine, Kindai University, Osaka-Sayama, Japan PubMed articles Google scholar articles
Yuya Shirai Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan PubMed articles Google scholar articles
Makoto Kawaguchi Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan Department of Urology, National Defense Medical College, Tokorozawa, Japan PubMed articles Google scholar articles
Mikiya Takao Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan Department of Surgery, National Defense Medical College, Tokorozawa, Japan PubMed articles Google scholar articles
Ryo Sugiyama Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan PubMed articles Google scholar articles
Yuzo Takada Faculty of Medical Science, Teikyo University of Science, Tokyo, Japan PubMed articles Google scholar articles
Takahiro Nakamura Laboratory for Mathematics, National Defense Medical College, Tokorozawa, Japan PubMed articles Google scholar articles
Hiroshi Nakashima Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Japan PubMed articles Google scholar articles
Masashi Tsunoda Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Japan PubMed articles Google scholar articles
Inaho Danjoh Group of Privacy Controls, Tohoku Medical Megabank Organization, Sendai, Japan PubMed articles Google scholar articles
Atsushi Hozawa Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan PubMed articles Google scholar articles
Kazuyoshi Hosomichi Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan PubMed articles Google scholar articles
Yu Toyoda Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan PubMed articles Google scholar articles
Yu Kubota Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan PubMed articles Google scholar articles
Tappei Takada Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan PubMed articles Google scholar articles
Hiroshi Suzuki Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan PubMed articles Google scholar articles
Blanka Stiburkova Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Institute of Rheumatology, Prague, Czech Republic PubMed articles Google scholar articles
Tanya J. Major Department of Biochemisty, University of Otago, Dunedin, New Zealand PubMed articles Google scholar articles
Tony R. Merriman Department of Biochemisty, University of Otago, Dunedin, New Zealand PubMed articles Google scholar articles
Nagato Kuriyama Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan PubMed articles Google scholar articles
Haruo Mikami Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan PubMed articles Google scholar articles
Toshiro Takezaki Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan PubMed articles Google scholar articles
Keitaro Matsuo Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan PubMed articles Google scholar articles
Sadao Suzuki Department of Public Health, Nagoya City University Graduate School Medical Science, Nagoya, Japan PubMed articles Google scholar articles
Tatsuo Hosoya Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan Department of Pathophysiology and Therapy in Chronic Kidney Disease, Jikei University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Yoichiro Kamatani Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan PubMed articles Google scholar articles
Michiaki Kubo RIKEN Center for Integrative Medical Sciences, Yokohama, Japan PubMed articles Google scholar articles
Kimiyoshi Ichida Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan Department of Pathophysiology, Tokyo University of Pharmacy and Life Science, Hachioji, Japan PubMed articles Google scholar articles
Kenji Wakai Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan PubMed articles Google scholar articles
Ituro Inoue Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Japan PubMed articles Google scholar articles
Yukinori Okada Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan PubMed articles Google scholar articles
Nariyoshi Shinomiya Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan PubMed articles Google scholar articles
Hirotaka Matsuo Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan PubMed articles Google scholar articles
on behalf of Japan Gout Genomics Consortium (Japan Gout)
Google scholar articles

Correspondence to Hirotaka Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa 359-8513, Japan; hmatsuo{at}ndmc.ac.jp

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Citation

Nakayama A, Nakatochi M, Kawamura Y on behalf of Japan Gout Genomics Consortium (Japan Gout), et al

Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients

Annals of the Rheumatic Diseases 2020;79:657-665.

Publication history

Received November 15, 2019
Revised February 13, 2020
Accepted February 17, 2020
First published April 1, 2020.

Online issue publication

May 12, 2021

Copyright information

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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