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Correspondence response
Response to: ‘Correspondence on ‘Increased risk of systemic lupus erythematosus in patients with autoimmune haemolytic anaemia’’ by Huang and Zhang
  1. Han-You Mo1,2,
  2. James Cheng Chung Wei2,3,4,
  3. Xiao-Huan Chen2,5,
  4. Hsin-Hua Chen6,7,8,9,10
  1. 1 Department of Rheumatology, The Affiliated Hospital of Guilin Medical University, Guilin, China
  2. 2 Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan
  3. 3 Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan
  4. 4 Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan
  5. 5 Department of Rheumatology, Guilin Medical University, Guilin, China
  6. 6 Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan
  7. 7 Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
  8. 8 Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan
  9. 9 School of Medicine, National Yang-Ming University, Taipei, Taiwan
  10. 10 Institute of Biomedical Science and Rong Hsing Research Centre for Translational Medicine, Chung Hsing University, Taichung, Taiwan
  1. Correspondence to Dr Hsin-Hua Chen; shc5555{at}hotmail.com

https://doi.org/10.1136/annrheumdis-2020-219269

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    We thank Huang and Zhang1 for their interest in our article entitled ‘Increased risk of systemic lupus erythematosus (SLE) in patients with autoimmune hemolytic anaemia (AIHA): a nationwide population-based cohort study’.2 In our article, we used nationwide longitudinal population-based data to explore the incidence of systemic lupus erythematosus (SLE) in patients with autoimmune haemolytic anaemia (AIHA) and demonstrated that patients with AIHA are at a very high risk of incidental SLE.2 Huang and Zhang1 have put forward valuable comments and opinions on our article.

    First, Huang and Zhang1 proposed that patients with childhood-onset SLE may be more likely to develop AIHA than adulthood-onset patients, and suggested that we describe the incidence of AIHA in patients with SLE of different age groups. Given that it is impossible to provide such information using our original data, we conducted another nationwide cohort study to investigate the risk of AIHA in patients with SLE stratified by age groups (ie, <18 years and ≥18 years). Using the 1997–2013 Taiwanese National Health Insurance Research Database (NHIRD), we identified 6781 newly diagnosed patients with SLE from 2006 to 2013 and randomly selected 130 340 age, sex-matched (1:20) individuals without SLE from one million representative populations. From the cohort, we used propensity score matching (PSM) (1:2) for age, sex, comorbidities and potential confounders (online supplemental table 1). Before …

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    Footnotes

    • Handling editor Josef S Smolen

    • H-YM and JCCW contributed equally.

    • Contributors H-YM and JCCW conceptualised the research and drafted the manuscripts. X-HC interpreted the data and drafted the manuscript. H-HC contributed to the research design, performed data analysis and graph generation, and critically revised the manuscript. All authors read and approved the final manuscript.

    • Funding This work was supported by funding from Chung Shan Medical University Hospital (grant number CSH-2018-C-023) and the National Natural Science Foundation of China (grant number 81760298).

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

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