Background: Low vitamin D levels may increase pain sensitivity, especially by increasing central sensitivity. Fibromyalgia is associated with an imbalance in neurotransmitters and inflammatory pathways in the central nervous system, leading to central sensitization of pain signals.

Objectives: The aim of this study was to investigate the relationship between Vitamin D level and pain, pain catastrophizing, function, depression and anxiety.

Methods: A total of 153 patients with FMS and 153 healthy individuals were included in the study. Vitamin D levels were recorded with 5 ml blood samples obtained from patients and healthy individuals. McGill Pain Questionnaire -Short Form (MPQ), Pain Catastrophizing Scale (PCS), Hospital Anxiety and Depression Scale (HADS) and Fibromyalgia Impact Questionnaire (FIQ) were used to evaluate pain, pain catastrophizing, psychological symptoms and function, respectively. Our study received approval from the Ethics Committee at Firat University (2022/14-02) and all patients were informed verbally and in writing about the study and signed a consent form.

Results: Vitamin D levels were statistically lower in the FMS group (17.71±9.32 ng/ml) compared to the control group (20.40±9.33) (p<0.05). When, no statistical difference was found among classified according to vitamin D subgroups in FIQ, MPQ, PCS and HADS (p>0.05). There was a negative correlation between vitamin D levels and MPQ, all subgroups of PCS (p>0.05), while no significant correlation was found among Vitamin D level and depression, anxiety and function. Our study received approval from the Ethics Committee at Firat University (2022/14-02) and all patients were informed verbally and in writing about the study and signed a consent form.

Conclusion: It was found that vitamin D levels of patients with FMS were lower than those of healthy individuals and VD levels were associated with pain and pain catastrophizing in this study. VD supplementation may improve pain catastrophizing in patients with FMS.

REFERENCES: [1] Armstrong DJ, Meenagh GK, Bickle I, Lee ASH, Curran ES, Finch MB. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clinical rheumatology. 2007;26:551-4.

Acknowledgements: NIL.

Disclosure of Interests: None declared.