Association of methotrexate polyglutamates concentration with methotrexate efficacy and safety in patients with rheumatoid arthritis treated with predefined dose: results from the MIRACLE trial

Hiroya Tamai; Kei Ikeda; Toshiaki Miyamoto; Hiroaki Taguchi; Chang-Fu Kuo; Kichul Shin; Shintaro Hirata; Yutaka Okano; Shinji Sato; Hidekata Yasuoka; Masataka Kuwana; Tomonori Ishii; Hideto Kameda; Toshihisa Kojima; Yurie Nishi; Masahiko Mori; Hideaki Miyagishi; Genta Toshima; Yasunori Sato; Wen-Chan Tsai; Tsutomu Takeuchi; Yuko Kaneko

doi:10.1136/ard-2024-226350

Article info

Rheumatoid arthritis

Association of methotrexate polyglutamates concentration with methotrexate efficacy and safety in patients with rheumatoid arthritis treated with predefined dose: results from the MIRACLE trial

Authors

Hiroya Tamai Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Kei Ikeda Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, JapanDepartment of Rheumatology, Dokkyo Medical University, Mibu, Japan PubMed articles Google scholar articles
Toshiaki Miyamoto Department of Rheumatology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan PubMed articles Google scholar articles
Hiroaki Taguchi Department of Internal Medicine and Center for Arthritis and Rheumatic Disease, Kawasaki Municipal Kawasaki Hospital, Kawasaki, Japan PubMed articles Google scholar articles
Chang-Fu Kuo Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan PubMed articles Google scholar articles
Kichul Shin Division of Rheumatology, Department of Internal Medicine, Seoul Metropolitan Government—Seoul National University Boramae Medical Center, Seoul, South Korea PubMed articles Google scholar articles
Shintaro Hirata Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan PubMed articles Google scholar articles
Yutaka Okano Division of Rheumatology, Department of Medicine, National Hospital Organisation Tokyo Medical Center, Tokyo, Japan PubMed articles Google scholar articles
Shinji Sato Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan PubMed articles Google scholar articles
Hidekata Yasuoka Division of Rheumatology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan PubMed articles Google scholar articles
Masataka Kuwana Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Tomonori Ishii Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan PubMed articles Google scholar articles
Hideto Kameda Division of Rheumatology, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan PubMed articles Google scholar articles
Toshihisa Kojima Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Orthopedic Surgery, National Hospital Organization Nagoya Medical Center, Nagoya, Japan PubMed articles Google scholar articles
Yurie Nishi Medical Headquarters, Eisai Co, Ltd, Tokyo, Japan PubMed articles Google scholar articles
Masahiko Mori Medical Headquarters, Eisai Co, Ltd, Tokyo, Japan PubMed articles Google scholar articles
Hideaki Miyagishi Clinical Data Science Department, Eisai Co, Ltd, Tokyo, Japan PubMed articles Google scholar articles
Genta Toshima Biostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan PubMed articles Google scholar articles
Yasunori Sato Department of Biostatistics, Keio University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Wen-Chan Tsai Department of Allergy, Immunology, and Rheumatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan PubMed articles Google scholar articles
Tsutomu Takeuchi Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, JapanSaitama Medical University, Iruma, Japan PubMed articles Google scholar articles
Yuko Kaneko Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
MIRACLE Study Group
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Correspondence to Dr Yuko Kaneko; ykaneko.z6{at}keio.jp

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Citation

Tamai H, Ikeda K, Miyamoto T MIRACLE Study Group, et al

Association of methotrexate polyglutamates concentration with methotrexate efficacy and safety in patients with rheumatoid arthritis treated with predefined dose: results from the MIRACLE trial

Annals of the Rheumatic Diseases Published Online First: 04 October 2024. doi: 10.1136/ard-2024-226350

Publication history

Received July 1, 2024
Accepted September 16, 2024
First published October 4, 2024.

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