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  • Response to: ‘Correspondence on ‘Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort’ by Ventura et al’

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Correspondence response
Response to: ‘Correspondence on ‘Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort’ by Ventura et al’
  1. Juliette Chommeloux1,
  2. Marie Pouletty2,
  3. Naim Ouldali2,3,
  4. Mathieu Kerneis4,
  5. Alexis Mathian5,
  6. Raphaele Mestiri6,
  7. Julien Rohmer7,
  8. Guillaume Hekimian1,
  9. Isabelle Melki2,8
  10. Great Paris Region (GPR) Kawa-COVID-19 consortium
  1. 1 Sorbonne Université, Institut de Cardiométabolisme et Nutrition (ICAN), Service de Médecine Intensive Réanimation, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
  2. 2 General Paediatrics, Infectious Disease and Internal Medicine Department, Reference Center for Rheumatic, AutoImmune and Systemic Diseases in Children (RAISE), Hôpital Robert Debre, AP-HP, Paris, France
  3. 3 UMR 1123, ECEVE, INSERM, Paris, France
  4. 4 Sorbonne Université, ACTION Study Group, INSERM UMRS1166, ICAN—Institute of CardioMetabolism and Nutrition, Institut de Cardiologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France
  5. 5 Sorbonne Université, Assistance Publique–Hôpitaux de Paris, Groupement Hospitalier Pitié–Salpêtrière, French National Referral Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome and Other Autoimmune Disorders, Service de Médecine Interne 2, Institut E3M, Inserm UMRS, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France
  6. 6 Internal Medicine Service, Bégin Military Teaching Hospital, Saint-Mandé, France 7 Service de Médecine Interne, Hôpital Foch, Suresnes, France
  7. 7 Service de Médecine Interne, Hôpital Foch, Suresnes, France
  8. 8 Laboratory of Neurogenetics and Neuroinflammation, Imagine Institute, Paris, France
  1. Correspondence to Dr Isabelle Melki,

https://doi.org/10.1136/annrheumdis-2020-218984

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    We thank Ventura et al for their correspondence1 on our study on paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (MIS-TS) mimicking Kawasaki disease (KD) (Kawa-COVID-19).2 They report a 38-year-old woman with a KD-like presentation following SARS-CoV-2 infection and highlight the need for physicians to be aware of this syndrome also in adults. We fully agree that, despite being initially described and more frequent in children, a similar presentation may occur following SARS-CoV-2 infection in adults.3 To assess similarities and differences between paediatric and adult cases, we collected data of nine adult cases of Kawa-COVID-19 in three hospitals of the Great Paris region (six were previously reported in another case series3) and compared them with our paediatric Kawa-COVID-19 cohort.2 The main characteristics of adult and paediatric patients are described in table 1.

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    Table 1

    Comparison between paediatric Kawa-COVID-19 cohort and adult Kawa-COVID cohort

    Median (range) age of the adults was 25 (19–33) years and 55% were male. None of the adults had criteria for complete KD while 10/16 children had complete KD criteria. Adults and children shared similar characteristics including fever, gastrointestinal and …

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    Footnotes

    • Handling editor Josef S Smolen

    • Collaborators Great Paris Region (GPR) Kawa-COVID-19 consortium: Charlotte Borocco, MD, Marion Caseris MD, Romain Basmaci MD, PhD, Noémie Lachaume MD, Philippe Bensaid MD, Samia Pichard MD, Hanane Kouider MD, Guillaume Morelle MD, Irina Craiu MD, Corinne Pondarre MD, PhD, Arielle Maroni MD, Mehdi Oualha MD, PhD, Zahir Amoura MD, MSc, Julien Haroche MD, PhD, Fanny Bajolle MD, PhD, Stéphane Bonacorsi MD, PhD, Guislaine Carcelain MD, PhD, Isabelle Kone-Paut MD, Karim Aacha MD, Brigitte Bader-Meunier MD, Albert Faye, MD, PhD, Ulrich Meinzer, MD, PhD, Caroline Galeotti MD, PhD Johanna Lokmer, MD, Cherine Benzouid, MD, Constance Beyler, MD, Anna Deho, MD, Glory Dingulu, MD, Laurent Gilardin, MD, Clément Dubost, MD.

    • Contributors JC, MP, NO, GH and IM designed the study and wrote the paper. All authors collected clinical data. GH and IM supervised the study. All authors have read final approval of the version published.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Commissioned; internally peer reviewed.

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